Death on the slopes

نویسندگان

  • Christina K. McPhee
  • Jahda H. Hill
  • Mari Enoksson
چکیده

Introduction The field of cell-death research has matured since pioneering discoveries showed that apoptosis is regulated genetically. Although many of the core caspase-signalling pathways are known, some of the most basic aspects of the biochemistry of mitochondrial apoptosis induction have remained elusive and are, in certain cases, controversial. Research on the metabolic dysfunction that occurs in cancer cells has led to the emergence of new drug targets, and recent studies have identified novel cell-death pathways. These exciting developments were discussed at the recent Keystone Symposium on Cell Death Pathways in Whistler, Canada. Many elegant studies were presented at the meeting; unfortunately, we cover only a few key topics here owing to space limitations. This report highlights presentations on the connections between cell death and mitochondrial dynamics, metabolism and cancer, and non-apoptotic cell death.

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تاریخ انتشار 2013